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In three phase 2 clinical ocular trials during which patients self-administered 0.1% T4 eye drops 2 to 6 times per day for 28 days reported no evidence of any adverse events

doi:10.1016/j.pneurobio.2014.11.004 Evidence-Base Disclosure The published evidence base for Dihexa consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments

The key detail for patient-facing content is that GHK-Cus status depends on the route of administration, so injectable and non-injectable forms should not be described the same way

For patients with severe cases of anemia or B12 vitamin deficiencies, a form of vitamin B12 called Hydroxocobalamin is sometimes used and does require a prescription